Adenosine Injection, USPFOR RAPID BOLUS INTRAVENOUS USE
DESCRIPTION
CLINICAL PHARMACOLOGY
Mechanism of Action
Hemodynamics
Pharmacokinetics
Clinical Trial Results
INDICATIONS AND USAGE
Intravenous adenosine injection is indicated for the following. Conversion to sinus rhythm of paroxysmal supraventricular tachycardia (PSVT), including that associated with accessory bypass tracts (Wolff-Parkinson-White Syndrome). When clinically advisable, appropriate vagal maneuvers (e.g., Valsalva maneuver), should be attempted prior to adenosine administration. It is important to be sure the adenosine solution actually reaches the systemic circulation (see DOSAGE AND ADMINISTRATION).1Adenosine injection does not convert atrial flutter, atrial fibrillation, or ventricular tachycardia to normal sinus rhythm. In the presence of atrial flutter or atrial fibrillation, a transient modest slowing of ventricular response may occur immediately following adenosine injection administration.
CONTRAINDICATIONS
- Second- or third-degree A-V block (except in patients with a functioning artificial pacemaker).
- Sinus node disease, such as sick sinus syndrome or symptomatic bradycardia (except in patients with a functioning artificial pacemaker).
- Known hypersensitivity to adenosine.
WARNINGS
Heart Block
Arrhythmias at Time of Conversion
Bronchoconstriction
PRECAUTIONS
Drug Interactions
Carcinogenesis, Mutagenesis, Impairment of Fertility
Pregnancy Category C
Pediatric Use
Geriatric Use
ADVERSE REACTIONS
Cardiovascular
Respiratory
Central Nervous System
Gastrointestinal
Post Marketing Experience (see WARNINGS)
Cardiovascular
Respiratory
Central Nervous System
OVERDOSAGE
DOSAGE AND ADMINISTRATION
Adult Patients
Pediatric Patients
HOW SUPPLIED
- Paul T, Pfammatter. J-P. Adenosine: an effective and safe antiarrhythmic drug in pediatrics. Pediatric Cardiology 1997; 18:118-126.