DESCRIPTION SECTION
Propofol injectable emulsion, USP is a sterile, nonpyrogenic white or almost white, homogeneous emulsion, containing 10 mg/mL of propofol, USP suitable for intravenous administration. Propofol, USP is chemically described as 2,6-diisopropylphenol and has a molecular weight of 178.27. The structural formula is:
Propofol, USP is slightly soluble in water and, thus, is formulated in a white, oil-in-water emulsion. The pKa is 11. The octanol/water partition coefficient for propofol, USP is 6761:1 at a pH of 4.5 to 7.4. In addition to the active component, propofol, USP the formulation also contains soybean oil (100 mg/mL), glycerol (22.5 mg/mL), egg phospholipids (12 mg/mL); and benzyl alcohol (0.15%); with sodium hydroxide to adjust pH. Propofol injectable emulsion, USP is isotonic and has a pH of 5.5 to 7.4.